Ketamine for depression – A Powerful but Tricky Solution
Ketamine is a very powerful anesthetic drug that’s made it’s way into psychiatry. In this video I talk in detail about how Ketamine is used to treat depression.
Ketamine is known on the street as special K. It’s a hallucinogen and induces dissociation which is a detachment from your environment. In clinical medicine, it’s a drug primarily used to start and maintain anesthesia.
In 2000 the first randomized controlled trial showed that Ketamine produced rapid improvement of depression. It’s not FDA approved yet for the use of depression. It’s going to take more studies AND we need more answers about long term safety. But currently we are using it as an IV infusion to treat depression. A new nasal spray was recently approved, called Spravato for treatment resistant depression. It is designed to be taken along with an antidepressant.
Ketamine as a Rapid-Acting Antidepressant: Promising Clinical and Basic Research
Andrew N. Tuck and Danish H. Ghazali. American Journal of Psychiatry Residents’ Journal 2017 12:3, 3-5
Canuso C, Singh J. et. al. Efficacy and Safety of Intranasal Esketamine for the Rapid Reduction of Symptoms of Depression and Suicidality in Patients at Imminent Risk for Suicide: Results of a Double-Blind, Randomized, Placebo-Controlled Study. American Journal of Psychiatry 2018 175:7, 620-630
Grunebaum, M et. al. Ketamine for Rapid Reduction of Suicidal Thoughts in Major Depression: A Midazolam-Controlled Randomized Clinical Trial. American Journal of Psychiatry 2018 175:4, 327-335
Sanacora G, Frye MA, McDonald W, et al. A Consensus Statement on the Use of Ketamine in the Treatment of Mood Disorders. JAMA Psychiatry. 2017;74(4):399–405.
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